Wobble hypothesis and codon-anticodon pairing describe:

• A. Wobble permits non-Watson-Crick pairing at the third codon position; an anticodon with inosine can pair with A, U, or C in the codon.
• B. Wobble prevents any non-standard base pairing.
• C. Wobble applies only to initiation codons.
• D. Wobble causes tRNA to pair with all codons.

Answer: (D)

Wobble describes how codon–anticodon interactions at the third base of the codon aren’t strictly locked to Watson–Crick pairs. This flexibility means a single tRNA anticodon can recognize several codons that code for the same amino acid. A central example is an anticodon that contains inosine; inosine can pair with A, U, or C in the codon. That small bit of versatility is what lets one tRNA read multiple codons, reducing the number of distinct tRNAs the cell needs while still maintaining accurate translation.

It’s important to note that wobble isn’t a blanket pairing with every possible codon. The flexibility has limits, and wobble applies to decoding rather than initiation. So the feature described by wobble is the selective, position-3 nonstandard pairing that expands codon recognition for a given tRNA, rather than universal or all-encompassing pairing.