Which enzyme performs C-to-U RNA editing in mammals?

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Multiple Choice

Which enzyme performs C-to-U RNA editing in mammals?

Explanation:
Cytidine deamination in RNA is carried out by APOBEC family enzymes, which convert cytidine to uridine. In mammals, APOBEC1 is the classic editor that edits specific mRNAs, including apolipoprotein B mRNA, where a C-to-U change creates a premature stop codon and yields a shorter protein. ADAR enzymes, by contrast, perform A-to-I editing, not C-to-U, while DNA polymerase and reverse transcriptase are involved in DNA synthesis or RNA-to-DNA transcription, not RNA base editing. So APOBEC is the enzyme that performs C-to-U RNA editing in mammals.

Cytidine deamination in RNA is carried out by APOBEC family enzymes, which convert cytidine to uridine. In mammals, APOBEC1 is the classic editor that edits specific mRNAs, including apolipoprotein B mRNA, where a C-to-U change creates a premature stop codon and yields a shorter protein. ADAR enzymes, by contrast, perform A-to-I editing, not C-to-U, while DNA polymerase and reverse transcriptase are involved in DNA synthesis or RNA-to-DNA transcription, not RNA base editing. So APOBEC is the enzyme that performs C-to-U RNA editing in mammals.

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